Ema Anastasiadou’s Topics
1.TITLE: Construction of a integrated, easy-to-handle and -modify, graph database for exploring interconnected clinical and genomic data of Alcohol Liver Disease.
ABSTRACT (less than 100 words):
Alcoholic Liver Disease (ALD) is a heterogeneous and complicated condition, poorly understood. To elucidate ALD, we aim to generate an integrated, easy-to-handle and modify, flexible graph database that will include epidemiologic, clinical, biochemical, molecular and medical data from patients and healthy controls, collected from the European consortium GALAXY (http://www.livergalaxy.eu/). The graph database will be designed with respect to user experience principles, offering real-time queries automatically transformed to visualizations where the only user-action needed will be to select the data relevant to user’s needs. All the above will be developed using state of the art technologies taking care of scalability issues.
2.TITLE: Manipulation and interpretation of Alcohocl Liver Disease RNA sequencing Data through bioinformatic analysis.
ABSTRACT (less than 100 words):
The main contributor to the generation and progression of liver disease is alcohol over-consumption. Excessive alcohol-use over a prolonged period of time results in Alcoholic Liver Disease (ALD). The spectrum of ALD includes steatosis, steatohepatitis, alcoholic fibrosis and cirrhosis. Its pathophysiology is not completely understood due to its heterogeneous and complicated nature. The proposed thesis is aiming to dissect ALD and unravel the networks implicated in the causality and advancement of the disease by the analysis of RNA sequencing data generated in the context of the GALAXY European consortium. The dataset refers to healthy and ALD participants.
NAME & POSITION OF THE SUPERVISOR:
Ema Anastasiadou
Researcher Level D
Biomedical Research Foundation of Athens Academy (BRFAA)
LAB/GROUP, DEPARTMENT, INSTITUTION where the thesis will be executed:
Anastasiadou’s Laboratory
Department of Genetics
Biomedical Research Foundation of Athens Academy (BRFAA)